Our dog was diagnosed a month ago. The vet tried the Wisconsin protocol and his blood work showed no results and than gave him one dose of L-Esparganaze which his blood work only got worse. She now wants to try Leukeran (Chlorambucil). When do you decide to give up and let your dog just live out his life without trying to prolong it a few more months. Does anyone know if Leukeran will even help. We do not see anything online with any type of results. is the doctor just trying to keep us spending our money is what we are starting to feel. Our dog has many good days still but a few he seems to just be very tired. He still goes for walks but limited in distance and eats very well. Our vet said their is no scientific reasons why his blood numbers are abnormal given that his lymph nodes have shrunk to normal levels now.